Photochemicalbiology for the Identification of Basal E3:POI Interactome

Time: 9:30 am
day: Day One

Details:

• Known molecular glues for TPD increase the avidity of a weak basal interaction between an E3 Ligase and a Protein of Interest
• A broadly robust technology to identifying these weakly productive basal interactions in a cellular context does not exist. Thus the discovery of molecular glues has historically been serendipitous
• Seed has advanced the area of photochemicalbiology and has demonstrated local interactome mapping to identify cellularly relevant weak basal interaction between an E3 Ligase and a Protein of Interest

Speakers: